Kinetics of Diphenylhydantoin Disposition in Man

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Effects of diphenylhydantoin on atrioventricular conduction in man.

The effects of intravenous diphenylhydantoin (5 mg/kg) on atrioventricular conduction in man at controlled heart rates in the digitalized and undigitalized state were studied. In undigitalized subjects, diphenylhydantoin administration consistently decreased A-V conduction time in each individual subject when identical heart rates were compared. Ouabain infusion produced an increase in A-V cond...

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The effect of diphenylhydantoin on thyroxine metabolism in man.

The effect of 5,5'-diphenylhydantoin on thyroxine metabolism was examined in five normal volunteers. Intravenous injection of radiothyroxine was followed by a 10-12 day control and subsequent 9-14 day treatment periods. During oral administration of diphenylhydantoin, plasma thyroxine concentration decreased to about 80% of its pretreatment level and the plasma radiothyroxine disappearance rate...

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Effects of Diphenylhydantoin on Atrioventricular Conduction in Man By RICHARD

The effects of intravenous diphenylhydantoin (5 mg/kg) on atrioventricular conduction in man at controlled heart rates in the digitalized and undigitalized state were studied. In undigitalized subjects, diphenylhydantoin administration consistently decreased A-V conduction time in each individual subject when identical heart rates were compared. Ouabain infusion produced an increase in A-V cond...

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ژورنال

عنوان ژورنال: Chemical and Pharmaceutical Bulletin

سال: 1970

ISSN: 0009-2363,1347-5223

DOI: 10.1248/cpb.18.405